Fascination About ketamine and seizures
Metabolism Ketamine is metabolized by using N-dealkylation to the Lively metabolite norketamine primarily by CYP2B6 and CYP3A4 and to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation in the cyclohexone ring to form hydroxynorketamine compounds via CYP-dependent pathways, whi